Overview

Dehydroepiandrosterone (DHEA) and its sulfate form (DHEAS) are key precursors for sex steroids, with elevated levels indicating increased adrenal androgen production. Mild elevations are usually idiopathic, but 5-fold or higher increases can suggest an androgen-secreting adrenal tumor. Pronounced elevations are common in congenital adrenal hyperplasia (CAH) due to enzyme deficiencies, particularly in children.

 When to Do a DHEAS Test (Indications)

Doctors usually order a DHEAS test when they suspect hormonal imbalance or adrenal gland issues.

For Women

✔ Excess hair growth (hirsutism)

✔ Acne that is severe or persistent

✔ Irregular or absent periods

✔ Symptoms of PCOS

✔ Male-pattern baldness

✔ Deepening voice or increased muscle mass (signs of high androgens)

For Men

✔ Low libido

✔ Erectile issues

✔ Suspected adrenal disorders

For Children

✔ Early puberty

✔ Excessive body hair

✔ Rapid growth of muscles or bones

For Both

✔ Suspected adrenal tumors

✔ Congenital adrenal hyperplasia (CAH)

✔ Adrenal insufficiency (low adrenal function)

What Preparation for the DHEA-SULFATE Test

Usually no special preparation is needed.

BUT there are a few important points:

✔ You may need to avoid:

• Biotin supplements (vitamin B7) for 24 hours
• Hormonal medications (only if doctor advises)
• Steroid medications may affect results

✔ Timing

The test can usually be done any time of day, because DHEAS levels do not change much during the day.

✔ Fasting

Not required.

How the DHEA-SULFATE Test Is Done

The DHEAS test is a simple blood test.

1. A lab technician cleans your arm.
2. A needle is inserted into a vein.
3. A small blood sample is taken.
4. The sample is analyzed in the lab.

It usually takes just 2–5 minutes.

No pain except mild sting.

Interpretation of DHEA-SULFATE Results (What the Results Mean)

📌 High DHEAS

May indicate:

• PCOS
• Adrenal tumor (rare, but possible)
• Congenital adrenal hyperplasia (CAH)
• Overactive adrenal glands
• High androgen production

Symptoms often include: acne, hair growth, irregular periods.

📌 Low DHEAS

May indicate:

• Adrenal insufficiency (Addison’s disease)
• Aging (levels naturally drop)
• Pituitary gland problems

Symptoms include: fatigue, low energy, low libido.