VITAMIN B-12
VITAMIN B-12
Observations Included- Holotranscobalamin (Active Vitamin B12)
Overview
Overview
Vitamin B12 in plasma binds to two proteins: transcobalamin (active, cell-available) and haptocorrin (inactive). Measuring holo-transcobalamin (holoTC) is thus more clinically relevant than total B12. Deficiency is also indicated by elevated homocysteine (tHcy) and methylmalonic acid (MMA) levels, as both accumulate when cellular B12 is low.
What is the Vitamin B-12 Test?
A Vitamin B-12 test measures the amount of Vitamin B-12 in your blood.
Vitamin B-12 is essential for nerve health, brain function, and red blood cell formation.
It helps detect whether your body has normal, low, or high levels of Vitamin B-12.
What is the Purpose of the Vitamin B-12 Test?
The test is mainly done to:
- Check for Vitamin B-12 deficiency
- Find the cause of weakness, fatigue, or memory problems
- Diagnose nerve issues like tingling or numbness
- Detect types of anemia (especially Pernicious & Megaloblastic anemia)
- Monitor people who have digestive issues affecting absorption
- Evaluate nutritional status in vegetarians/vegans
When is a Vitamin B-12 Test Recommended?
Your doctor may recommend the test if you have:
Symptoms of Low B-12
- Fatigue / weakness
- Tingling or numbness in hands or feet
- Balance problems
- Mood changes / depression
- Memory issues
- Pale skin
Medical Conditions
- Anemia
- Nerve problems (neuropathy)
- Digestive disorders (Crohn’s, Celiac, Gastritis)
- Weight-loss/ bariatric surgery
- Chronic alcohol use
Lifestyle Factors
- Vegetarian or vegan diet (low natural B-12 intake)
- Poor diet or malnutrition
Preparation for a Vitamin B-12 Test
Usually no special preparation is required.
But for accurate results:
- Some labs may ask for 8–10 hours fasting (not always mandatory).
- Inform your doctor if you take:
- Vitamin supplements
- Folic acid
- Biotin
- Certain medicines (these can affect results)
How is the Vitamin B-12 Test Done?
The test is simple:
- A lab technician takes a blood sample from your arm.
- The sample is sent to the laboratory.
- Results usually come within a few hours to 1 day.
It is a quick, painless test (only a small needle prick).
What is the Cost of a VITAMIN B-12 Test ?
The Price of VITAMIN B-12 Test is Rs. 800. However, cost of the test may fluctuate depending on following factors:
- Other tests advised along with Vitamin B-12 Test
- Offers or discounts
- Empanelment of the patient